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Dosing, Routes of Administration, and Protocols Disclaimer: The following dosing information is drawn from published preclinical research and emerging clinical use patterns

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"Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the diet-induced obese rat." PLoS One 9.10 (2014): e109841

Commercially available GLP-1 patches lack clinical evidence for safety and efficacy and might lead to adverse reactions

However, this same mechanism is responsible for nausea, bloating, vomiting, and early satiety, especially when the body has not yet adapted to the drug