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The titration protocol exists because GLP-1 receptor agonists cause gastrointestinal side effects, primarily nausea, that are dose-dependent

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[73] [74] [75] It is synthesized by some bacteria in the gut microbiota in humans and other animals, but it has long been thought that humans cannot absorb this as it is made in the colon, downstream from the small intestine, where the absorption of most nutrients occurs