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Pregnancy and breastfeeding excluded from the trial

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STEP 1 for semaglutide 2.4 mg

Clinical trials of semaglutide and tirzepatide have not shown consistent evidence of thyroid dysfunction in patients without pre-existing thyroid disease

Targeting parasite oxidative capacity can re-sensitise resistant parasites Artemisinin resistant parasites have a more reduced oxidative status and we have previously shown that artemisinin disproportionately alkylates proteins involved in parasite redox homeostasis and that disrupted redox processes are involved in the artemisinin mechanism of action 4