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For ESCC induction, 4-nitroquinoline 1-oxide (Sigma, Shanghai, China) was dissolved in propylene glycol (Sigma) and diluted in the drinking water at a final concentration of 100 g ml 1

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subjects whose samples were not used for the 2D analysis), including four non-splenectomized -thalassemia/HbE patients, five splenectomized -thalassemia/HbE patients and 8 healthy volunteers