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The side chain of arginine contains a guanidinium group, with a pKa as high as 12.5, which means that arginine remains stably positively charged over almost the entire physiological pH range and can form complex bidentate hydrogen-bonding networks

They provide ~5-6 doses at the RECONNECT 1.75mg protocol, which fits inside the documented reconstitution stability window for nasal/SC bremelanotide