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16 A sub-study of the SURPASS-3 trial on overweight/obese patients with T2DM demonstrated that tirzepatide decreased liver fat by 8.1% over 52 weeks, along with significant reductions in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (NCT03882970), 17 indicating that tirzepatide may improve liver steatosis or inflammation

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Its phase 2 and phase 3 data set spans thousands of participants across the SURPASS and SURMOUNT trial programmes, giving researchers an extensive published literature base against which to calibrate experimental design and expected outcomes