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39 The previous study suggested that mouse CBS is regulated by NRF2, likely through an ARE in the upstream region of the gene

It is predominantly metabolised by CYP3A4 in the liver into the N-monodesmethyl (M2) metabolite, which exhibits anti-tubercular activity, albeit with approximately five times less potency than the parent drug

Dosage Tips Gradual Increase : Start at a lower dose to allow the body to adapt to increased glutathione synthesis

For urine acyglycine testing, we placed 8-ml aliquots of random urine samples at 4 C overnight without removal of cells or sediment, and submitted to Mayo Clinic Laboratories for metabolite quantification by gas chromatography/mass spectrometry (test code AGU20)

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