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Standard Escalation Protocol The Phase 2 trials used a gradual escalation approach designed to minimize gastrointestinal side effects while building to therapeutic doses

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In another aspect, the regions of the linkers that may be protonated to carry a positive charge include amino groups, such as polyaminoalkylenes including ethylene diamines, propylene diamines, butylene diamines and the like, and/or heterocycles including pyrollidines, piperidines, piperazines, and other amino groups, each of which is optionally substituted

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