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A meta-analysis of three randomized controlled trials in patients with existing vascular disease found a benefit of B-vitamin supplementation on prevention of recurrent stroke (HR, 0.71

In a study published in 2017, the long-term use of metformin (Glucophage), an anti-diabetic medication, was correlated with a lower risk of gallstones in diabetic subjects (Liao 2017)

The FDA classifies it as a Category 2 bulk drug substance, noting potential safety concerns in unregulated compounding

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