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Concurrently, preclinical studies have shown that the co-administration of GIP and GLP-1 into the cerebral ventricles enhances additional weight reduction benefits [86]

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GLP-1 drugs work by slowing digestion and reducing appetite

The buffering of antioxidant species can be accomplished by reduced glutathione (GSH), that is also required for phase II detoxification in which endogenous and exogenous toxic metabolites are conjugated to GSH for their removal [10], [11]