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Semaglutide has not been shown to cause kidney damage or kidney disease in clinical studies

Their experiences sometimes make it into conference presentations or anecdotal reports

These are one of, if not the most rigorously studied class of peptides ever, with many large, placebo-controlled, randomized trials that followed over the past twenty years from the original GLP-1 drugs such as exenatide, approved by the FDA in 2005

Of note are the preferential distributions of the transsulfuration pathway and the catabolizing enzyme glycine N-methyltransferase in mammalian tissues such as liver and kidney (Finkelstein, 1990)

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