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They are better viewed as potential complements to conventional treatment, not substitutes

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Our findings appear confirmative of previous observational studies and may help in selecting septic shock patients with a higher likelihood to show a hemodynamic response to AVP as a second-line vasopressor

Competing Interests Professor Melanie Davies has acted as a consultant/advisor and speaker for Eli Lilly, Novo Nordisk and Sanofi, has attended advisory boards for Abbvie, Amgen, AstraZeneca, Biomea Fusion, Carmot/Roche, Sanofi, Zealand Pharma Regeneron, GSK and EktaH and as a speaker for AstraZeneca and Boehringer Ingelheim

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