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In ERS state, HSPs may participate in the process of apoptosis through Fas/caspase8 pathway and be exposed on the cell membrane (111), while HSPs may be passively released into extracellular matrix during cell death

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An important difference from tretinoin is that it is less irritating on the skin and has less side effects which is why it is one of the few retinoids that can be used by patients as young as 9 years of age 28

Suwannatrai A, Suwannatrai K, Haruay S, Piratae S, Thammasiri C, Khampoosa P, Kulsantiwong J, Prasopdee S, Tarbsripair P, Suwanwerakamtorn R, Sukchan S, Boonmars T, Malone JB, Kearney MT, Tesana S

The parathyroid glands, which sit on the posterior surface of each thyroid lobe, produce parathyroid hormone (PTH), which regulates calcium homeostasis