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19, conjugates described herein that include a linker comprising at least one unnatural amino acid, such as EC1496, are less toxic than the corresponding conjugate that does not, such as comparative example EC0746

Unlike vitamins, LC is synthesized endogenously in humans but becomes conditionally essential under certain physiological demands, such as prolonged or high-intensity exercise (Alesci et al

These results are shown in Table 1

Healthcare professionals have not identified any serious side effects from high-dose vitamin B12 supplementation

Obviously, when the patients receive the injections in the clinic, there's a lot less room for error than if they have to go home and do it themselves