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FEBS Lett 86:8991 Anderson ME, Meister A (1980) Dynamic state of glutathione in blood plasma

SLC6A14 and SLC38A5 drive the glutaminolysis and serine-glycine-one-carbon pathways in cancer

Some other critical roles assigned to glutathione in the body include: Neutralization of superoxide radicals Cofactor for several antioxidant enzymes Regeneration of vitamins C and E Neutralization of free radicals produced by liver metabolism of chemical toxins Transportation of mercury out of cells and the brain Regulation of cellular proliferation Vital to mitochondrial function and maintenance of mitochondrial DNA (mtDNA) Glutathione has been shown to be very important in helping prevent hyperpigmentation, helping to prevent melanogenesis, the generation of melanin in the skin

There are many topical depigmenting agents such as hydroquinone, glycolic acid, arbutin, kojic acid, Vitamin C, Vitamin E and niacinamide

This research was supported by the National Natural Science Foundation of China (82505462)