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References Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, et al

Through creatine recycling via creatine kinase, ingestion of 3 g of creatine monohydrate can help store 50 kcal energy in the skeletal muscle of a 70-kg person for supporting a 60-min intensive exercise (i.e., 483 mmol creatine phosphate/whole-body skeletal muscle/min 20/142 = 68 mmol = 68 mmol 12.3 kcal/mol 0.001 60 min = 50 kcal)

As muscles adapt to reduced glycogen stores, localized spasms may occur, particularly in larger muscle groups

For example, Mycobacterium tuberculosis (Mtb) infection is associated with the reduced levels of GSH and GPX4, along with increased lipid peroxidation, which further lead to necrotic cell death

Important contributors to reduced hemolysis are reduced splenic conditioning with decreased erythroid vesicles release, reduced erythrophagocytosis, and a proresolving profile of splenic macrophages