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Obesity and hypertension promote renal tumorigenesis through mechanisms involving insulin-like growth factor signaling, chronic inflammation, and altered renal hemodynamics, and are consistently identified across multiple cohort studies as among the most important modifiable risk factors for RCC [279]

Seiler, Sarah E., Koves, Timothy R., Gooding, Jessica R., Wong, Kari E., Stevens, Robert D., Ilkayeva, Olga R., Wittmann, April H., DeBalsi, Karen L., Davies, Michael N., Lindeboom, L., Schrauwen, P., Schrauwen-Hinderling, Vera B