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Bypassing the digestive system, glutathione enters the body quickly and offers an instant increase in antioxidant levels

showed "GSH was highly tolerated and its administration was not associated with any signs of adverse effects." [2] Blood chemistry markers, including liver and kidney function tests, remain unaffected even with extended use

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This is because antioxidants have more work to do and more oxidants to mop up before their effects start to be felt/seen