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Protein disulfide isomerase-mediated apoptosis and proliferation of vascular smooth muscle cells induced by mechanical stress and advanced glycosylation end products result in diabetic mouse vein graft atherosclerosis

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The authors of the study wrote that the potential mechanisms behind these effects include "L-carnitine's role in transporting fatty acids across mitochondrial membranes, enhancing beta-oxidation, reducing free fatty acid availability, and inhibiting cholesterol synthesis." In addition, the authors noted, "L-carnitine exhibits antioxidant and anti-inflammatory properties, which can further modulate dyslipidaemia (the imbalance in blood lipids) and protect LDL from oxidative stress." Finally, it was reported that L-carnitine was able to reduce the conversion of free fatty acids to triglycerides, and ultimately prevent the build-up of triglycerides