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Here are two notable studies that outline the GH-increasing effects of both CJC-1295 and ipamorelin: CJC-1295 administered as a subcutaneous injection to healthy study volunteers resulted in an increase in overall GH levels while maintaining GH pulsatility, with peak levels staying within normal ranges

The findings from this study indicate that the Modified GRF 1-29 analog may potentially affect the growth hormone IGF-1 signaling pathway

In the brain, they are most highly expressed in the hypothalamus, specifically the ventromedial nucleus and arcuate nucleus

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This is a key reason dosing should remain at or below the saturation threshold