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Gimnez-Cassina, Front

In Experiment 2, due to limited sample size, data from both sexes were pooled and analyzed using oneway ANOVAs for cumulative curve and acute administration measures

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Mounjaro 15 mg achieved an HbA1c reduction of 2.30% compared with 1.86% for Ozempic

The L-cells in the intestinal epithelium express various nutrient-sensing receptors: Dietary fats are particularly potent GLP-1 secretagogues, activating free fatty acid receptors (such as GPR40 and GPR120) on L-cells Proteins and amino acids stimulate GLP-1 through peptide-sensing mechanisms and calcium-sensing receptors Carbohydrates trigger release via glucose transporters and sweet taste receptors expressed on enteroendocrine cells Dietary fibre , particularly soluble fibre, promotes GLP-1 secretion through fermentation products (short-chain fatty acids) produced by gut microbiota The rate and site of nutrient delivery also influences GLP-1 response