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[196], leptin levels are not only increased in asthma, but leptin itself increases airway hyperreactivity and pro-inflammatory cytokines levels in BALF when administered during sensitization in the OVA allergic asthma model in mice [196]

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This accumulation further exacerbates mitochondrial ROS production, creating a vicious cycle that accelerates cellular aging and contributes to various age-related pathologies, including CVDs [161, 172]

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