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Semaglutide treatment significantly reduced depressive- and anxiety-like behaviors, preserved synaptic plasticity, reversed hippocampal neuroinflammation, increased hippocampal serotonin (5-HT), serotonin transporter (5-HTT), and glutamatergic receptor expression

No major interactions have been found

Novo Nordisk is continuing to take multiple proactive measures to keep patients aware of potentially unsafe and unapproved knockoff alternatives and informed of how to access authentic, FDA-approved medicines

Reportedly, glutamate is involved in maladaptive neuroplastic processes contributing to generation and maintenance of pain and mood disorders (Riggs and Gould, 2021)

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