Importantly, synthetic GPR40 agonists are efficacious GLP-1 secretagogues both in vitro in primary cultures, in perfused intestines and in vivo when studied in mice [252,294,295]
The six groups included (i) control group, (ii) stress group, (iii) group with DSIP one hour before stress experiments, (iv) DSIP 24 hours before stress experiments, (v) DSIP one hour before the last stress experiment and (vi) DSIP 24 hours before the last stress experiment
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