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Identify gaps in the literature and ongoing research directions Key gaps include a lack of large, controlled clinical trials, unclear optimal dosing and delivery for reproductive targets, limited long-term safety data for systemic use, and few mechanistic human studies linking molecular changes to fertility outcomes

Some reports of liver issues have appeared with other GLP-1 drugs, but like semaglutide, the risk seems to be very low

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Moreover, GLP-1 receptors interact with various neurotransmitter systems such as serotonin, dopamine, and glutamate, which are essential for mood regulation and may contribute to the onset of depression and other psychological disorders [82]

In patients with Fournier's gangrene, serious outcomes have included multiple surgeries and death