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In laboratory investigations, MT-1 functions as a melanocortin receptor agonist, binding to and activating members of the melanocortin receptor family (MC1R, MC3R, MC4R, MC5R)

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observed in Nature Medicine , NNMT inhibition in adipose tissue produced favorable body composition changes without negatively impacting muscle mass (Kraus et al., Nature Medicine )

A combination of crista dotted and parallel furrow patterns, termed peas-in-a-pod pattern, was the most common dermatoscopic feature noted in the acral CMN (38 %)

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