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This inhibition is associated with a reduction in mitochondrial membrane potential, suppression of ATP synthesis, and oxidation of endogenous NAD(P)H and protein thiol groups

Expanded reimbursement increases the number of eligible patients, requiring pharmaceutical companies to adjust marketing, physician education, payer engagement, and commercial planning strategies

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HR: 2.75

Since hippocampal atrophy is a hallmark of major depression, compounds that protect and potentially restore hippocampal tissue address a fundamental aspect of the disease process