However, there are uncertainties about the long-term efficacy of the drug and what happens when people stop taking it
Researchers also looked at safety, which was similar to other drugs in this class, making oral semaglutide a strong choice for eligible patients
Repeated the above amino acids coupling and Fmoc deprotection steps with remaining amino acids as per the amino acid sequence of Semaglutide by using Fmoc-Gly- OH, Fmoc-Arg(pbf)-OH, Fmoc-Val-OH, Fmoc-Leu-OH, Fmoc-Trp(Boc)-OH, Fmoc-Ala- OH, Fmoc-Ile-OH, Fmoc-Phe-OH, Fmoc-Glu(OtBu)-OH, Fmoc-Lys(Boc)-OH, Fmoc-Ala- OH, Fmoc-Ala-OH, Fmoc-Gln(Trt)-OH, Fmoc-Gly-OH, Fmoc-Glu(OtBu)-OH, Fmoc-Leu- OH, Fmoc-Tyr(tBu)-OH, Fmoc-Ser(tBu)-OH, Fmoc-Ser(tBu)-OH, Fmoc-Val-OH, Fmoc- Asp(OtBu)-OH, Fmoc-Ser(tBu)-OH, Fmoc-Thr(tBu)-OH, Fmoc-Phe-OH, Fmoc-Thr(tBu)- OH, Fmoc-Gly-OH, Fmoc-Glu(OtBu)-OH coupled to H-Arg(Pbf)-Gly-CTC resin by linear approach to get the title compound
However, oral bioavailability of semaglutide is lower than injectable, meaning the effective dose may differ from what injection patients experience
c) recovering the expressed semapeptide
