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GLP-1RA/tesaglitazar does not differ from the pharmacokinetically matched GLP-1RA in GLP-1R signalling, but shows GLP-1R-dependent PPAR-retinoic acid receptor heterodimerization and enhanced improvements of body weight, food intake and glucose metabolism relative to the GLP-1RA or tesaglitazar alone in obese male mice

Additionally, key genes involved in decidualization including FOXO1, NOTCH1, NANOG, WNT4, KLF4, OCT4, SOX2, and LIN28A, as well as angiogenesis-related genes such as HIF1A, VEGFR-2, and VEGFR-3, were significantly upregulated

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This serves as a call for more proactive research efforts on the topic of GLP-1 RA use in patients undergoing concurrent EGD and colonoscopy in order to help develop guidelines and cautious risk mitigation policies for the peri-procedural management of this patient population