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Cellular Senescence in Kidney Dysfunction Cellular senescence is defined by a permanent growth arrest of damaged cells with commonly enlarged, flattened morphology, which secretes proinflammatory factors through SASP, resistance to apoptosis, senescence-associated heterochromatic foci (SAHF), DNA segments with chromatin alterations reinforcing senescence, the expression of senescence-associated beta-galactosidase (SA--gal), the expression of CDK inhibitor p16 and p21, the activation of p53, the expression of high-mobility group A (HMGA) proteins, and reduced lamin B1, among others

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