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KEAP1-NRF2 system as a potential therapeutic target in ALS The presence in ALS of increased levels of OS markers and impaired antioxidant defense in the brain and peripheral tissues [25] together with the central role of NRF2 in inducing target genes to counteract OS [272] make the KEAP1-NRF2 system a suitable therapeutic target for drugs and small molecules
Rodent studies [11, 56] have shown that central or peripheral administration of GLP-1R agonists reduces short-term food and water intake and lowers body weight
Clinical trials: Research studies conducted to evaluate the safety and effectiveness of medications like semaglutide
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