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Protein binding has little effect on the clearance of high-extraction drugs, as the liver's high metabolic capacity can efficiently remove the drug from binding proteins as it passes through

Results Childrens characteristics A total of 5,247 eligible children and adolescents were finally included, with the mean age of 10.67 (0.05) years

At the same dose, a 74 kg participant had about 1.4 times the exposure of a 110 kg reference, while a 143 kg participant had about 0.8 times. Weight alone does not set the dose, but it helps explain why the trial mean transfers poorly to bodies outside the studied range

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