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11 However, a dose-specific analysis revealed that the beneficial effect of efpeglenatide on HF hospitalisation was primarily seen in the 6 mg group, in which there was a 50% RRR in HF hospitalisation (HR 0.50)

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To advance translational applications, future studies should focus on: (1) transforming dynamic biomarkers into clinical decision-making tools, such as evaluating early changes in circulating mitochondrial-derived vesicles or oxidative stress markers (e.g., 8isoprostaglandin F2 (8-iso-PGF2))to predict subsequent biochemical and histological responses