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The striatum and substantia nigra (SNc)-ventral tegmental area (VTA) regions were used for the stereological analysis, with specific cell markers such as tyrosine hydroxylase (TH), neuropeptide Y (NPY), and somatostatin (SST) quantified in these regions

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A double-blind study with chronic insomnia patients showed: Higher sleep efficiency compared to placebo Shorter sleep onset times Reduced subjective tiredness measures Researchers note that effects were modest and some changes might reflect placebo group variations rather than direct DSIP action

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