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NPs hold great promise for targeted drug delivery, but their safe use hinges on several factors: cellular toxicity (NPs must not harm brain cells or disrupt neural functionthis requires careful design to ensure biocompatibility and minimal cytotoxicity), immunogenic responses (NPs should not trigger adverse immune reactions, which could lead to inflammation or other complications in the brain), and efficient clearance (it is crucial that NPs are effectively cleared from the body after delivering their therapeutic payload, because accumulation in organs or tissues could lead to long-term toxicity) [160]

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Immune system failure could lead to uncontrolled replication of the SARS-CoV-2 virus, secondary infections and continuous shedding of the virus in patients who die from COVID-19 regardless of the time passed from the start of the infection (Ruan et al., 2020

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