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Conclusions In this large real-world cohort of patients with type 2 diabetes and pre-existing aortic aneurysm, GLP-1RA therapy was associated with significantly lower risks of aortic rupture/dissection, hypertensive crisis, and all-cause mortality compared with DPP-4i therapy

Riddle MC, Cefalu WT, Evans PH et al (2021) Consensus Report: Definition and Interpretation of Remission in Type 2 Diabetes

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Molecules can cross the tight junctions via two distinct size-selective and charge-selective paracellular pathways: the pore pathway and the leak pathway

Both semaglutide (Ozempic, Wegovy) and tirzepatide (Zepbound) are designed for once-weekly dosing and that long-acting design means they don't leave your body quickly either