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The concept of dose stepping, using a higher dose for initial weight loss and then transitioning to a lower dose for maintenance, could become the standard treatment paradigm if the data supports it

No matter what weve done, weve not been able to nail precisely why they are resistant. Unexpected resistance The researchers focused on two variants that disrupt an enzyme called PAM (peptidyl-glycine alpha-amidating monooxygenase), which activates several hormones, including GLP-1

Larbig, W., Gerber, W., Kluck, M., & Schoenenberger, G

No hormonal crosstalk

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