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As a transcription target of p53, the activity of spermidine/spermine N 1 -acetyltransferase 1 (SAT1), the rate-limiting enzyme in polyamine catabolism, induces lipid peroxidation and sensitizes cells to undergo ferroptosis and the deletion of SAT1 suppresses p53 and p53 3 KR -mediated ferroptosis

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Both groups then received an injection of fentanyl (75 g/kg, IV) and BT was recorded 5, 10, 15, 20, 25 and 30 min later