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Neuen BL, Fletcher RA, Heath L, Perkovic A, Vaduganathan M, Badve SV, et al

Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Journal of Biological Chemistry

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Results ACE inhibits proliferation and promotes cell death in colorectal cancer cells Inspired by the problems of drug resistance, metastasis, and side effects of paclitaxel, oxaliplatin, and 5-FU and the advantages of the specificity and broad spectrum of natural drugs used in cancer treatment, we selected RKO cells, a poorly differentiated human colon cancer cell line sensitive to cell death, to screen for antitumor activity in a natural compound library