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These effects have been demonstrated in various models of neurotoxicity and oxidative stress, including D-galactose-induced cognitive deficits [28], scopolamine- and cisplatin-induced cerebral oxidative damage [29] and amyloid-beta-induced memory impairment [30]

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Combining multi-omics analysis of the reproductive system with in-depth gut microbiome studies will not only uncover the systemic protective mechanisms of L-citrulline within the gut-testicle axis but also provide a scientific foundation for developing personalized, microbiome-informed nutritional strategies tailored to individual molecular phenotypes

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