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Experiments conducted on isolated bovine chondrocytes also revealed an apparent upregulation in the production of proteoglycans and collagen in these laboratory settings, fundamental components of the extracellular matrix considered essential for cartilage integrity

Certain populations need to inject B12 in larger doses to maintain baseline health: Individuals with pernicious anemia are initially injected with 100 mcg daily for one week, followed by 100 mcg every other day for 3-4 weeks