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GLP-1RAs have direct anti-atherosclerotic effects in euglycemic mice, ApoE -/- mice or Watanabe heritable hyperlipidemic (WHHL) rabbits in a GLP-1R-dependent manner [56-58]

After the activation of p38 and JNK in MAPK pathway, they can also enter the nucleus and upregulate the expression of related inflammatory cytokines, induce the expression of MMPs and downregulate TGF- expression, thus playing an important role in the UV-mediated photodamage [31, 32] (Fig

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