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Data availability All raw LCMS/MS plasma metabolomics data generated during this study are publicly available in Figshare at References Bralten J, van Hulzen KJ, Martens MB, Galesloot TE, Arias Vasquez A, Kiemeney LA, Buitelaar JK, Muntjewerff JW, Franke B, Poelmans G

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The ROC curves for the evaluation of PENs-induced AD with the individual metabolites were shown in Fig

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