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Pan-ERR activation by SLU-PP-332 **bypasses the need to stimulate PGC-1alpha via physical exercise**, making it the first credible "exercise mimetic" class candidate with complete pharmacokinetic profile

a , GLP-1:Tesa

s -Cysteinylation of SOD1 prevents the inhibitory action of hydrogen peroxide on SOD1, 207,208 which contributes to an increased antioxidant potential of cancer cells and thereby protects them from oxidative damage