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[9] An increased proportion of pheomelanin is associated with lighter skin colour

An exaggerated inflammatory response is also implicated during the development of many lung diseases and this is further exacerbated by depleted glutathione (GSH) levels

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It also supports detoxification by binding to toxinssuch as heavy metals, pesticides, and environmental pollutantsand facilitating their removal

To investigate whether IRE1 mediates ferroptosis sensitivity through regulation of GSH availability, we measured cellular GSH levels in MDA-MB-231 cells with differential IRE1 expression