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FDA described insufficient clinical safety information, characterisation concerns and inadequate evidence of effectiveness for its reviewed use

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Until well-designed human studies are conducted, McGuire and his co-authors concluded, the substance should be approached cautiously

For these reasons, PregS more closely resembles the characteristics of classical neurotransmitters, such as acetylcholine, in which the parent molecule bears a full positive charge and is active only at an extracellularly directed recognition site while the immediate breakdown products (choline + acetic acid) are inactive