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These can include mild irritation when applied topically

Unlike full HGH, it does not raise IGF-1 levels significantly , so its unlikely to have the side effects associated with growth hormone therapy (like blood sugar swings or joint pain)

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Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: systematic review of observational studies involving 34,000 patients

You had just hit on so many great points and foreshadowing of multiple questions I have on my list, but I think its so important in just setting our patients up for the right expectations