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Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme that catalyzes the calcium-dependent transamidation reaction between glutamine and lysine residues of proteins to form crosslinked proteins

Patients should be gentle with the area around the puncture site for a couple of days, and can apply an ice pack for 10 to 20 minutes at a time if they notice any bruising or swelling, ensuring a thin cloth is placed between the skin and the ice pack to avoid direct contact

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The identification of selenium-independent isoforms, such as GPx7, has broadened our understanding of the familys functional diversity and suggests the existence of additional regulatory mechanisms beyond classical selenium-dependent catalysis