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278 : 19071916 Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai L-H

Amyloid-beta suppresses AMP-activated protein kinase (AMPK) signaling and contributes to alpha-synuclein-induced cytotoxicity

The use of FAs rather than carbohydrates when CoA levels are limited could potentially be driven by a lower K m for acyl-CoA synthetases compared with that for pyruvate dehydrogenase 60,61

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So even the topical route, which is the evidence-backed one, should be described as supported by small, sometimes industry-affiliated human cosmetic studies with modest effect sizes, not as proven. The correct posture toward topical GHK-Cu is cautious optimism grounded in real but imperfect human data which is still a materially stronger position than the injectable route can claim