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This guidance clarifies the need for developers to explicitly define context of use and demonstrate that a NAM is biologically relevant, technically robust, and fitforpurpose to support regulatory decisionmaking within that context

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Dosing NAC at 6001200mg daily increases hepatic glutathione production by supplying cysteine without the bioavailability constraints of intact glutathione

Once things calm down, you can usually restart at the same or a lower dose

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